Last updated on January 27th, 2023 at 12:23 pm
Pathology labs are used by doctors to diagnose diseases. Pathology lab services are used by medical professionals to diagnose diseases. Find out what they do and how they work!
Health care providers may be unfamiliar with the workings of the pathology laboratory. The delivery of a specimen to the pathology laboratory starts a complex series of events, resulting in a pathological diagnosis/interpretation. The following section reviews the importance and key objectives in the pathologic evaluation of tissue and provides information on the types and members of the pathology laboratory.
What are Pathology Laboratory Services?
Quick Jump Table
The diagnosis of cancer is not conclusively established, nor safely assumed, in the absence of a tissue diagnosis, nor should definitive therapy for cancer, with rare exception, be undertaken. Policies supporting this practice are written into the bylaws of most hospitals and are regularly monitored by hospital tissue committees and accrediting agencies.
The goal of pathology examination of tissue is to provide accurate and sufficiently comprehensive diagnoses to enable the treating physician to develop an optimal plan of treatment. There are hundreds of varieties of tumours, most with characteristic biology, that require accurate diagnosis by pathologists. Data on markers with prognostic and predictive significance are also routinely incorporated into pathology reports, allowing for individualized treatment plans for patients. It is not only important to get sufficient tissue for a specific diagnosis of malignancy, but for many malignancies, additional tissue is required for prognostic and predictive ancillary studies.
While some have postulated that we are moving toward a gene/mutation-driven categorization of tumours replacing disease site clinics and treatment planning (e.g., PIK3CA mutated carcinomas instead of “ovarian” cancer or “breast” cancer), data is accumulating that histology, morphology, disease site location and microenvironment besides genomic changes are still important factors in understanding the disease biology for treatment planning.
Types of Pathology Laboratory Services
- Hospital labs
Almost all hospitals contain a laboratory to support the clinical services offered at the hospital. The specific pathology services would include both anatomic (surgical pathology, cytopathology, autopsy) and clinical (laboratory medicine) pathology at most hospitals. Most, if not all, inpatient and many outpatients seen by hospital-affiliated physicians require tests performed by hospital labs.
- Reference labs
Reference labs are usually private, commercial facilities that do both high volume and speciality (high complexity and/or rare) laboratory testing. Most of these tests are referred from physician’s offices, hospital facilities and other patient care facilities such as nursing homes. Reference labs, typically at a site other than the healthcare facilities, are often used for specialized tests that are ordered only occasionally or require special equipment for analysis.
- Public health labs
Public health laboratories are typically run by state and local health departments to diagnose and protect the public from health threats, such as outbreaks of infectious disease. These labs perform tests to monitor the prevalence of certain diseases in the community, which are a public health concern, such as outbreaks of food-borne or waterborne illnesses or detection of unique infectious agents.
Members Of The Pathology Laboratory Services
The staff of most clinical laboratories is diverse. A non-comprehensive summary of the major individuals found in these laboratories is provided below.
Anatomic pathology, which encompasses surgical pathology, cytopathology and autopsy pathology, includes:
- Pathologists: Physicians with special training in the diagnosis and detection of disease. Practising pathologists may be subspecialty or general pathologists, depending on the cases they review daily. Some pathologists may perform a subspecialty fellowship in a specific area of pathology, such as cytopathology, hematopathology, dermatopathology, neuropathology, neuropathology, etc.
- Pathologist’s assistants: These individuals assist with the gross description and dissection of surgical cases and biopsies, working closely with supervising pathologists. Pathologist’s assistants may also assist in the technical aspects of intraoperative assessment, such as frozen section and selection of tissue for research and clinical trials (tissue procurement).
- Cytotechnologists: These individuals help screen specimens that are composed of small samples of cells rather than entire sections of tissue, e.g., Pap smear specimens. After screening and marking diagnostic cells in slides, a cytotechnologist refers cases with abnormal cells to pathologists for review. Other common cytologic specimens include fine needle aspirations (FNAs), washings or scrapings of cells and other body fluids.
- Histotechnologist: These individuals manage the processing of tissue in the laboratory and perform the technical components of making slides from tissue for evaluation by a pathologist. These components include fixing the tissue, embedding it in paraffin, sectioning tissue onto slides and staining the tissue on slides.
Clinical Pathology Services
Clinical pathology, which encompasses laboratory medicine, includes the following;
- Pathologists/PhD scientists: These professionals provide direction for clinical labs to ensure accurate and timely reporting of lab tests and serve as a resource for result interpretation to clinicians. Individuals often have specific training in one or more of the following areas: clinical chemistry, microbiology, molecular pathology, haematology, immunology, and blood banking.
- Medical laboratory technicians: These health care professionals perform laboratory testing and analysis on body fluids and other specimens to help determine the presence or absence of disease.
- Phlebotomists: These health care professionals are trained to draw blood from a patient for clinical testing, transfusions, donations, or research. Commonly called lab technicians.
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Pathology Laboratory Services in Pune
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You may also interest in reading: What is Pathology?
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