Double Marker Test

Description

Dual Marker Test in Pregnancy

A Double marker test is a type of test that is mainly given to pregnant women to determine any chromosomal malformation in the foetus. This test also plays a vital role in the detection of any kind of neurological conditions in the fetus, such as down’s syndrome or Edward’s Syndrome. Chromosomal abnormalities in the foetus can cause serious developmental deformities and lead to various health problems in the child post-birth, but such abnormalities are extremely rare.

The Double Marker Test is especially given to pregnant women above 35 years of age and those who have a family history of birth defects and a history of insulin-dependent type 1 diabetes.

What is the double marker test?

A double marker test is a specific blood test performed on pregnant women to detect any chromosomal malformations in the fetus. This test is usually recommended for women above 35 years of age because they are at high risk of giving birth to a baby with chromosomal abnormalities. However, even younger women who are less than 35 years of age are also asked to undergo this test during pregnancy.

Why doctor advise double marker blood test during pregnancy?

The varied uses of the Double Marker Test are as follows;

• It helps in assessing whether the unborn baby is at risk for any mental disorder
• It is used primarily for the detection of Down syndrome
• Double Marker Test also helps to detect Trisomy 18, that results in mental retardation and severe birth defects
• It also helps in the detection of Trisomy 21.T, which causes mental disorders, heart disorders and other health conditions affecting vital organs

Why this double marker test is performed?

The double marker test is a proven test for detecting any abnormalities or any issues present. This test finds out the abnormalities in the chromosomes of the fetus. The abnormalities in the chromosomes may lead to serious conditions like the growth of the baby may be affected. With the help of this double marker test disorders such as Edwards syndrome, Down’s syndrome can be detected.

Edward’s syndrome is a condition that leads to severe developmental delays because of a chromosome 18 abnormality. Down’s syndrome is the delay of growth, development, and intelligence because of chromosome 21 disorder. This test is usually conducted after 8 weeks to 14 weeks of pregnancy. This test is recommended in women above 35 years of age or in women with a family history of birth defects or if the first child has birth defects or has a history of Type-1 diabetes (insulin-dependent).

1. Free BHCG
2. PAPPA (pregnancy Associated plasma protein-A)

A Double Marker Test is done with an ultrasound test and is done with a blood sample. The Double Marker Test looks for two markers, namely Free Beta hCG (human chorionic gonadotrophin) and PAPPA (Pregnancy-associated plasma protein A).

Free Beta hCG is a glycoprotein hormone produced by the placenta during pregnancy. Its high level shows a higher risk of Trisomy 18 and Down’s syndrome.

PAPPA is a vital plasma protein. A low level of plasma protein shows the risk of down syndrome.

The test readings are signified in terms of screen positive, high risk, and screen negative.

Note:

• Do In 1st Trimester of Pregnancy
• Latest USG Report Required
• Overnight fasting is not required
• Doctor’s prescription may be needed
• The test result may vary depending on age, health history, etc.
• Ideal for pregnant female above 35yrs
• Before interpreting the results, one should keep in mind that this is not a diagnostic test but a screening test

Also known as, dual marker test, dual marker test in pregnancy, double marker test, double marker test in pregnancy, dual marker screening,

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