Blood Flow and Veins

What is Thrombophilia?

Last updated on August 1st, 2022 at 07:10 am

Thrombophilia is a condition where blood clots form more easily than normal. It can be caused by several factors, including genetic mutations. Thrombophilia is a condition where blood clots form more easily than normal. It’s caused by an inherited or gained deficiency of proteins involved in clotting. 

Thrombophilia are conditions where blood clots form too quickly or easily. They’re often associated with pregnancy, but they can also occur outside of pregnancy. In this article, we’ll discuss some of the most common causes of thrombophilia and what you can do about them.

What is Thrombophilia Medical Term?

Thrombophilia (also known as hypercoagulability) is a predisposition to the development of blood clots. Thrombophilia can be inherited or gained during one’s lifetime. Conditions leading to thrombophilia that can be gained or developed during one’s lifetime include abnormalities of the blood such as too many red blood cells (polycythemia) or too many platelets (thrombocytosis or thrombocythemia), placement of a mechanical heart valve, or the development of abnormal proteins or antibodies.

Most often, blood clotting is a good thing, a necessary response, in fact, to keep your body from bleeding excessively when you’re injured. But clotting, or coagulation as it’s also called, can be dangerous when clots form when they aren’t supposed to. That’s the case with deep vein thrombosis (DVT), blood clots that form in a vein deep inside the body, usually the legs.

Particularly at risk for this are people with a blood clot disorder called thrombophilia, also known as hypercoagulability. This condition makes someone more likely to develop abnormal blood clots, which can be life-threatening. Thrombophilia increases the DVT risk. And, left untreated, blood clots can break off, start moving through the blood, and block blood flow to a major organ, possibly causing severe damage or death. That’s why proper thrombophilia diagnosis is so important.

Most thrombophilia are genetic, meaning they’re inherited from one or both parents. There are also risk factors for blood clots that are not genetic, such as taking oral contraceptives, being immobilized because of recent surgery, or cancer. But most are inherited.

What is thrombophilia in pregnancy?

Pregnancy is a hypercoagulable state. The field of thrombophilia, the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications, such as severe preeclampsia intrauterine growth retardation abruption placentae and stillbirth, have been associated with thrombophilia.

Recurrent miscarriage and has also been associated with thrombophilia. Finally, thromboembolism in pregnancy as in the non-pregnant state is linked to thrombophilia. Read More (Previous image sourced)

Learn about cholesterol test

What is thrombophilia profile test?

These tests are comprises the usual thrombophilia profile;

  1. Antithrombin III activity
  2. Homocysteine level
  3. Ptt a d mixing studies
  4. Lupus anticoagulant
  5. Protein c antigen
  6. Free proteins
  7. Apc-activated protein c resistance
  8. Phospholipid antibody IgG & IgM
  9. Protein c activity
  10. Protein s activity
  11. Antithrombin iii antigen
  12. Anti-cardiolipin antibody
Thrombophilia profile test packages in pune

Learn about d-dimer test for DVT

Reference: StopTheClot

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