Tissue Transglutaminase Antibody Test
The tissue transglutaminase (tTG) test is done as a part of the assessment of certain autoimmune conditions, most particularly celiac disease. This test is done to diagnose celiac disease and to assess the effectiveness of a gluten-free diet. Detecting celiac disease where the body produces two antibodies that attack tTG can be effectively done by measuring the IgA form of tTG antibody available in the blood.
This way is very useful as it is made in the small intestine where inflammation and irritation are caused in sensitive people by gluten. This test is suggested to people showing symptoms of celiac disease, which includes anaemia and abdominal pain.
What is the tTG test?
Tissue Transglutaminase Antibody test is also known as Celiac disease antibody test or tTG. This test is done to detect celiac disease and also to determine the efficacy of a gluten-free diet.
The tTG antibody test is done;
- In case of symptoms of celiac disease such as chronic diarrhoea, bloating, pain in the abdomen, anaemia, and weight loss
- If an infant is irritable for a long time
- If an infant is not growing at a normal rate,
- In case of a family history of celiac disease
- In patients undergoing treatment for celiac disease
How to prepare for the tTG test?
Before the tTG test, sometimes for way as long as a week or more than suggested by your doctor have food that is rich in gluten like bread, pasta and baked goods, as the body will produce respective antibodies only when exposed to gluten. In case if gluten is ceased from the diet being taken, there won’t be any antibody response that is to be measured.
Things turn easier for both the patient and the lab technician if the clothing is worn is like T-shirt or short-sleeved shirt giving easy access to the parts where blood is to be squeezed.
Procedure for the anti tTG test
A lab technician will draw the blood from a vein in hand. For an infant, the blood is drawn from the heel by making a puncture with a small needle called a lancet and the blood is then collected into the vial. Where blood is drawn from a vein, the skin surface is cleaned with antiseptic and a tourniquet is placed around the upper arm or, in rare cases, some good enough pressure is applied manually for the veins to get swollen with blood.
A needle is then inserted into a vein and enough blood to test is withdrawn and collected in a vial or syringe.
tTG test result
The Anti-tTG test results can be positive or negative. A positive test result means a presumptive celiac disease. All positive tests are followed by an intestinal biopsy, which is used for a definitive diagnosis of celiac disease. A negative result means that the pre observed symptoms are not likely because of celiac disease.
Anti tTG Antibody Test
- Overnight fasting is not required. Talk to your doctor before booking the test.
- A doctor’s prescription may be required
- A previous medical history may be required
- Inform your doctor before the test and follow all of his/her advice.
tTG antibody test
TTG Test is also known ttg antibody test, anti ttg test, ttg antibodies test
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