tTG IgA Test

Description

tTG IgA Test

Tissue Transglutaminase Antibody – IgA test

What is tTG IgA?

Tissue Transglutaminase Antibody – IgA test is also known as Celiac disease antibody test or tTG. This test is done to detect celiac disease and also to determine the efficacy of a gluten-free diet.

Why is tTG IgA done?

The tissue transglutaminase antibody IgA test is done;

• In case of symptoms of celiac disease such as chronic diarrhoea, bloating, pain in the abdomen, anaemia, and weight loss
• If an infant is irritable for a long time
• If an infant is not growing at a normal rate,
• In case of a family history of celiac disease
• In patients undergoing treatment for celiac disease

What does tTG IgA test measure?

The tissue transglutaminase antibody – IgA test measures self-generated antibodies present in the blood which are produced by the body in response to autoimmune disorders such as celiac disease and other gluten-sensitive conditions. In celiac disease, an inappropriate immune response is generated to counter gluten. Gluten is a protein that is found in wheat, rye, and barley. 

Because of the immune response produced by the body, there is inflammation of the small intestine, which leads to damage and destruction of the villi that lines the walls of the intestine. Villi are finger-like structures present in the small intestine. These increase the surface area of the intestine and help in the digestion of food. They allow various nutrients, vitamins, minerals, electrolytes, and fluids to be absorbed into the body. 

If a person suffering from celiac disease gets exposed to gluten content, the body in response produces antibodies. These antibodies cause inflammation, which damages the villi. This damage will further affect the body’s ability to absorb food. In such conditions, the body develops signs and symptoms which are associated with malnutrition and malabsorption. 

Interpreting tTG IgA test results

Result (In Units) Interpretation

<20                        Negative

20-30                     Weak Positive

>30                         Positive

Note: The tTG IgA reference range may vary from lab to lab.

• A positive anti-tissue transglutaminase antibody IgA test usually shows celiac disease 
• A negative test usually means that symptoms are not likely because of celiac disease. If the person being tested has consumed no gluten for several weeks or months before the test, then the test may show false-negative results 
• All antibody tests for celiac disease are usually followed by an intestinal biopsy, which is the gold standard for diagnosis of this condition 

Is there any preparation required before the tissue transglutaminase antibody IgA test?

For an effective and correct diagnosis, a person should avoid any gluten-free diet or regime and should continue consuming gluten-rich foods before the test. However, if the test is done for monitoring the celiac disease, no preparation is required.

Which foods contain gluten?

It is possible to find a naturally present gluten in cereals and wheat. Gluten maintains the elastic texture of the dough and acts as a bonding factor to maintain the shape of the food. Gluten-containing food includes baked goods, pasta, soups, cereals, bread, sauces, and salad dressings. Apart from wheat, gluten is also found in cereals such as barley, bulgur, durum, semolina, rye, malt, farina, and triticale.

Does celiac disease fade away with time?

No, once a person is diagnosed with celiac disease, the person has to follow a gluten-free diet life long.

Is there any risk associated with the Tissue Transglutaminase IgA test?

There is no risk associated with the Tissue Transglutaminase IgA test, but in a few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can swell of the vein after the blood is withdrawn.

tTG IgA antibody test

Note:

• Overnight fasting is not required. Talk to your doctor before booking the test.
• A doctor’s prescription may be required
• A previous medical history may be required
• Inform your doctor before the test and follow all of his/her advice. 

tTG IgA Blood Test

tTG IgA test also known as ttg iga test, ttg iga, ttg iga antibody, ttg iga antibody test, ttg iga blood test,

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Read Our Article On Celiac Disease