What is Thrombophilia?
Thrombophilia (also known as hypercoagulability) is a predisposition to the development of blood clots. Thrombophilia can be either inherited or acquired during one’s lifetime. Conditions leading to thrombophilia that can be acquired or develop during one’s lifetime include abnormalities of the blood such as too many red blood cells (polycythemia) or too many platelets (thrombocytosis or thrombocythemia), placement of a mechanical heart valve, or the development of abnormal proteins or antibodies.
Most often, blood clotting is a good thing — a necessary response, in fact, to keep your body from bleeding excessively when you’re injured. But clotting, or coagulation as it’s also called, can be dangerous when clots form when they aren’t supposed to. That’s the case with deep vein thrombosis (DVT), blood clots that form in a vein deep inside the body, usually the legs.
Particularly at risk for this are people with a blood clot disorder called thrombophilia, also known as hypercoagulability. This condition makes someone more likely to develop abnormal blood clots which can be life-threatening. Thrombophilia increases DVT risk. And, left untreated, blood clots can break off, start moving through the blood, and block blood flow to a major organ, possibly causing severe damage or death. That’s why proper thrombophilia diagnosis is so important.
Most thrombophilias are genetic, meaning they’re inherited from one or both parents, There are also risk factors for blood clots that are not genetic, such as taking oral contraceptives, being immobilized due to recent surgery, or cancer. But most are inherited.
Thrombophilia in Pregnancy
Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications such as severe preeclampsia intrauterine growth retardation abruptio placentae and stillbirth has been shown to be associated with thrombophilia. Recurrent miscarriage and has also been associated with thrombophilia. Finally, thromboembolism in pregnancy as in the non-pregnant state is linked to thrombophilia.
- Anti thrombin III activity
- Homocysteine level
- Ptt & mixing studies
- Lupus anticoagulant
- Protein c antigen
- Free protein s
- Apc-activated protein c resistance
- Phospholipid antibody igg & igm
- Protein c activity
- Protein s activity
- Antithrombin iii antigen,
- Anti-cardiolipin antibody
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