Gliadin Antibody Test
Gliadin Antibody Test
A gliadin antibodies test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the body’s immune system mistakenly thinks that gluten, a protein in wheat, barley, rye, and oats, is a foreign invader. Gliadin is a portion of the protein found in gluten.
Gliadin antibody test for celiac
The immune system of someone who’s sensitive to gliadin produces anti-gliadin antibodies (AGA) to attack the protein. The antibodies are divided into two groups:
- immunoglobulin A (IgA)
- immunoglobulin G (IgG)
IgA is more useful in detecting celiac disease because it’s made in the small intestine, where gluten causes inflammation and irritation in sensitive people. IgG levels are less specific to celiac disease, but may still be used in diagnosing autoimmune problems, especially in people who are deficient in IgA.
Measuring the levels of both types of gliadin antibodies in the blood lets doctors assess the immune system’s response to gluten.
Why is gliadin antibody test advised?
The gliadin antibody test is used to help diagnose celiac disease or monitor its treatment.
How to prepared for gliadin antibody test?
For accurate results, one must be on a diet that includes gluten, such as wheat-containing bread, pasta, and baked goods. The body will only produce antibodies when it’s exposed to gliadin. If gliadin has been removed from your diet, there won’t be an antibody response to the measure.
The procedure of gliadin antibody test
Only a little blood is drawn for the test. A lab technician will usually draw the blood from a vein after cleaning the skin surface with antiseptic and placing an elastic band (tourniquet) around the upper arm to apply pressure and causing the veins to swell with blood. Then a needle is inserted into a vein (usually in the arm inside of the elbow or on the back of the hand) and blood is withdrawn and collected in a vial or syringe.
After the procedure, the elastic band is removed. Once the blood has been collected, the needle is removed, and the area is covered with cotton or a bandage to stop the bleeding. Collecting the blood for this test will only take a few minutes.
Collecting a blood sample is only temporarily uncomfortable and can feel like a quick pinprick. Afterwards, there may be some mild bruising, which should go away in a day or so.
Gliadin antibody test result
In the lab, the blood sample usually will undergo a test called an ELISA (enzyme-linked immunosorbent assay). This involves incubating the blood on a special plate with various chemicals. By measuring the intensity of the colour change that follows, doctors can tell whether gliadin antibodies are in the blood.
The results are usually available within 2-5 days since it’s a rare test.
If results show gliadin antibodies, the doctor will probably do other tests, which may include a biopsy of the small intestine to look for evidence of gliadin-induced inflammation.
Gliadin antibodies test condition;
- Overnight fasting is not required. Talk to your doctor before booking the test.
- A doctor’s prescription may be required
- A previous medical history may be required
- Inform your doctor before the test and follow all of his/her advice.
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