Anti-CCP Antibody Test (Anti-CCP)
The anti-CCP (anti-Cyclic Citrullinated Peptide) antibody test is a blood test that looks for anti-CCP antibodies (also called anti-citrullinated protein antibodies or ACPAs). These are a type of autoantibody: an antibody produced by the immune system that targets something that the body’s own tissues are made of. ACPAs target a type of protein that is called a citrullinated protein that can be found in some people’s joints.
The anti-CCP antibody test can be helpful in diagnosing Rheumatoid Arthritis (RA). ACPAs are present in 60-70% of people who get RA. Since not everyone with RA will test positive, doctors interpret the results of this test in context with their patient’s symptoms and the results of other tests.
This test’s results are important to consider because:
- In a healthy person without joint problems, a positive anti-CCP significantly increases the odds that the person will get RA in the future
- In a person in the early stages of arthritis, a positive anti-CCP significantly increases the odds of developing RA (even more so than having another type of antibody associated with arthritis, called Rheumatoid Factor or “RF”).
- In a person who has RA, a positive anti-CCP is a good predictor for erosive disease (a more severe condition where the bones can start to erode away).
The anti-CCP antibody test can help distinguish RA from other possible types of arthritis. The ACPAs it looks for are almost always associated with RA, they are not associated with many other types of arthritis, and they are only rarely found in certain other autoimmune conditions.
What are antibodies?
Antibodies are proteins and are normally made by the immune system in response to bacteria, viruses, and other foreign substances. Sometimes, however, antibodies are made when the immune system malfunctions and attacks the body’s own tissues, as happens in RA. Anti-CCP antibodies are of this type. They form in response to inflammatory proteins called citrullinated peptides. The antibodies are present in the blood of many people with RA from its very earliest stages, and even when a person’s arthritis is “undifferentiated” (meaning it’s not clear what type of arthritis it is). Researchers estimated roughly 95% of people with undifferentiated arthritis who test positive for anti-CCP antibodies eventually develop RA.
Learn More: RA FACTOR
What is the normal range of Anti CCP?
Any value lesser than 20U/ml is normal Anti CCP Antibody
Other tests with Anti CCP Test
Your doctor may refer other tests along with your Anti CCP Test to compare and better diagnosis, those are;
Anti CCP Test Cost
Average price range of Anti CCP test is between ₹500 to ₹3000 depending on the factors of city, quality and availability. Book Anti CCP Test at healthcare nt sickcare at ₹750.00
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